1-Butanethiol: Past, Present, and Where It’s Going

Historical Development

Long before most folks recognized the signature rotten odor of thiols, chemists in Europe were busy isolating odd-smelling compounds from various natural sources in the 1800s. 1-Butanethiol, also known as n-butyl mercaptan, caught their attention thanks to its punchy aroma. Early industrial labs marked it down as a chemical curiosity—something they’d stumble upon when working with petroleum byproducts or during fermentation experiments with yeast. As chemical industries grew throughout the twentieth century, demand for organosulfur compounds grew right alongside. 1-Butanethiol moved from being a compound studied for its structure to a practical intermediate in synthetic chemistry, especially for rubber and fuel additive producers. Its story tracks with advances in analytical chemistry. Gas chromatography and mass spectrometry made it easier to handle and measure, anchoring its role beyond just being “that stinky stuff.”

Product Overview

Today, 1-Butanethiol stands out as a colorless liquid. Most who work with it quickly point to its eye-watering, disagreeable smell—a sign of thiol groups doing their thing. Industrial firms package it up as a key ingredient for chemical syntheses. It helps manufacture agrochemicals and pharmaceuticals, but you’ll also find it in research labs as a marker in gas detectors. Producers label drums and bottles with hazard codes, control batch purity with gas chromatography, and keep everything sealed under nitrogen to stop the air from turning the contents foul or acidic. In most labs, you’ll see 1-Butanethiol taking up residence near fume hoods and tightly stoppered glassware.

Physical & Chemical Properties

Few materials draw such a sharp reaction in the world of laboratory odors. 1-Butanethiol appears as a clear, greasy-looking liquid just a touch less dense than water. Its chemical formula—C4H10S—hints at a short, straight four-carbon chain capped with a sulfur-hydrogen group. That simple structure gives it a low boiling point (around 98°C) and a volatility that makes it tough to forget if a bottle goes unsealed. Its solubility takes a hit in water, but it blends easily in organic solvents. The thiol group stands out for both reactivity and smell. Left in the open, 1-Butanethiol can oxidize, making handling and storage a key challenge. Simple tests in undergraduate labs—like reacting with heavy metal salts—show sharp color shifts, helping new chemists get a handle on its unique chemistry.

Technical Specifications & Labeling

Producers care about purity and water content. They ship most batches at technical or synthesis-grade quality, ensuring at least 99% purity for precision work. Common packaging ranges from amber glass bottles to steel drums lined in plastic. Labels display clear hazard codes (flammable and toxic), shipping details, use-by dates, and storage warnings. Regulators in the US and Europe keep a close eye on labeling, often requiring suppliers to list out all impurities above certain thresholds to flag risks for poisonings or side reactions. Barcodes and batch numbers give labs traceability—if a problem shows up, firms need to track down the origins quickly.

Preparation Method

Modern production of 1-Butanethiol typically starts with n-butyl chloride and hydrogen sulfide in the presence of sodium hydroxide, using a classic nucleophilic substitution. Large chemical plants carry out the reaction in sealed reactors, keeping moisture and air out while controlling temperature and pressure. Then the crude product heads through several distillation steps to strip out leftover reagents and water. Any impurities—especially disulfides or higher-molecular weight byproducts—get skimmed off, leaving a relatively pure product. Waste from this process contains plenty of sulfurous compounds, so plants run scrubbing systems to keep emissions in check.

Chemical Reactions & Modifications

1-Butanethiol’s reactive sulfur makes it a great target for more chemistry. It forms disulfides easily, either by air exposure or through deliberate oxidation—something perfumers and sulfur chemists use to tweak smells and stabilities. It hooks readily into alkylation and acylation reactions, sometimes serving as a handle to build bigger, more complex molecules. Chlorination, bromination, and other halogenation steps give derivatives with a range of properties, handy for refining rubber toughness or changing volatility. In academic labs, chemists tack on 1-butanethiol groups to ligands or catalysts, harnessing that stinky sulfur for its power to grab metal ions.

Synonyms & Product Names

Few chemicals carry around as many nicknames as 1-butanethiol. The industry leans on “n-butyl mercaptan” most, yet anyone in the business knows it by its IUPAC name, butane-1-thiol. You’ll see “butyl mercaptan” in old textbooks or company catalogs. Shipping manifests might say “1-sulfanylbutane.” Each name traces back to the sulfur's spot in the molecule. Anyone handling this stuff learns fast to watch for similar-sounding chemicals—mixing up n-, iso-, and tert-butyl mercaptan can bring headaches for supply chain folks, especially if a tank of the wrong material shows up at a facility relying on consistent product specifications.

Safety & Operational Standards

Lab techs and factory operators talk about 1-butanethiol safety with the same respect they give to concentrated acids. Even tiny spills stink up entire buildings, and inhalation causes nausea or headaches. Proper setups include explosion-proof storage, always with tight-fitting lids and vented cabinets. Chemical-resistant gloves and splash goggles should be standard. In case of a spill, absorbents and plenty of ventilation downplay exposure, while careful waste handling keeps contamination outside facility grounds. Emergency plans in responsible facilities go over ventilation, cleanup, and decontamination. Regulations require safety data sheets to spell out inhalation risks and fire hazards, as 1-butanethiol burns with a faint blue flame, giving off toxic fumes.

Application Area

Despite the tough handling, 1-butanethiol earns its keep across several fields. Manufacturers rely on it in the synthesis of intermediates for agrochemicals and pharmaceuticals. It plays a role in vulcanizing rubbers—a fact that means every vehicle tire and industrial gasket likely owes stability to the family of thiols. In natural gas plants, it’s been used to odorize otherwise scentless leaks—a tool that has saved lives by warning people of gas escapes. In research, it serves as a probe molecule for surface studies, helping scientists distinguish between hydrophilic and hydrophobic patches or track reactions on metal catalysts.

Research & Development

Lab teams continue probing the quirks of 1-butanethiol. Some push for new catalytic coupling reactions, aiming for greener routes with fewer hazardous byproducts. Materials scientists have begun attaching thiol groups to nanoparticles, hoping to craft smarter sensors or medical delivery vehicles. Analysis of trace 1-butanethiol in food chemistry sheds light on the origins of flavor (and sometimes off-flavors) in aged cheeses and beers. The sulfur’s affinity for making and breaking bonds pulls in organometallic chemists hunting for new catalysts, while environmental scientists follow degradation patterns in soil and wastewater, searching for more effective cleanup strategies.

Toxicity Research

Scientists treat 1-butanethiol’s pungency as more than a nuisance. Inhalation, even at low concentrations, triggers unpleasant symptoms—headache, nausea, and dizziness. Animal toxicity studies measure how quickly effects kick in, helping regulatory bodies set workplace exposure limits. Skin absorption tests flag irritation potential, which reminds industry labs to step up their glove and face shield routines. Chronic exposure studies delve into organ impact, particularly the liver and kidneys, putting pressure on companies to improve ventilation controls. Environmental surveys track how butanethiol and its breakdown products spread in waterways, as the sulfur-laden runoff can disrupt aquatic life. Faster, more accurate field tests for detection earn research dollars, and the ongoing studies feed into stiffer regulations.

Future Prospects

Change always stirs in the world of specialty chemicals. Research teams keep searching for safer, clearer ways to synthesize and handle thiols. More producers are switching to closed systems and better emission capture tech after pressure from new air quality laws. New uses for 1-butanethiol may appear in advanced materials, self-healing polymers, or even as building blocks for targeted drug delivery. As green chemistry gathers pace, expect more work on reducing or recycling sulfur wastes. Regulatory bodies will push for tighter controls, and companies will have new guidelines for trace impurities and workplace exposure. The story of 1-butanethiol is far from over. Each year brings discoveries that make it a little less mysterious, a little more useful, and, with luck, a lot safer for everyone involved.



What is 1-Butanethiol used for?

A Bitter Smell with a Big Job

Anyone who’s ever dealt with chemicals in a lab or factory remembers their first experience with 1-butanethiol. The smell is impossible to forget—sharp and rotten, like old skunk or strong onions. The punch in the nose isn’t an accident. Chemists use 1-butanethiol’s foul odor as a warning system because when something leaks, you know it right away.

Most people outside of specialized industries don’t realize this compound plays a crucial role in our safety. In natural gas pipelines and storage, leaks risk lives and property. By itself, natural gas doesn’t smell. Utilities add trace amounts of 1-butanethiol or similar compounds to create a stench so people catch leaks before disaster hits. This little trick makes cities and homes safer, and it saves lives—hard to ignore value from a chemical most only recognize for its stink.

Behind the Scenes in Manufacturing

Anyone who works around synthetic chemicals learns the building blocks early on. 1-Butanethiol serves as a vital ingredient in the production of rubber and pesticides. It helps shape tires, gloves, tubing, and hundreds of products tied to health and transport. The manufacturing process requires exact performance. Even small tweaks can change flexibility or strength. Using the right additive gives chemists control over the final product—especially in rubber, which has to protect drivers and workers every day.

In making pesticides, 1-butanethiol acts as both a building block and a reactive agent. It gives chemical designers new options for targeting pests without wrecking crops. Formulators test each variation because food and farm safety depend on results in the real world, not just in test tubes.

A Punchline—and a Teaching Tool

Few pranksters forget learning about stink bombs as kids. 1-Butanethiol famous for its gag-gift potential still gets used in small quantities to teach chemistry students and young science fans. Used right, the compound teaches respect for odors as warning signals, driving home the lesson that not all “bad” smells mean something’s wrong—sometimes, those smells protect us.

Hazard, Health, and Balance

Strong chemicals like 1-butanethiol demand careful handling. Symptoms from overexposure include headaches, nausea, and eye irritation. Industries using it long-term create strict training and safety standards. I’ve watched seasoned workers treat it with the same respect they show high-voltage electricity or heavy machinery. Nothing replaces vigilance and strong ventilation.

Waste management presents another challenge. Factories face pressure to keep environmental release low. Special scrubbers and neutralizers break down these smelly residues. Proper disposal avoids harming nearby communities and wildlife. Regulators stress regular inspection and swift response to spills for obvious reasons—nobody wants rivers or fields tainted by chemical runoff.

Room for Improvement

Engineers now look for replacements with less odor and lower risk. The aim—maintain safety while improving working conditions for everyone involved. Research teams study new methods that keep gas lines secure but don’t create as much headache for workers exposed on a regular basis.

From the outside, 1-butanethiol’s role rarely gets much credit. Beneath the stench, it’s quietly fighting fires, keeping families and worksites safer day in and day out. By understanding the balance between utility and health, we can find better ways to manage risks without giving up all the good this awkward-smelling compound delivers.

What are the hazards and safety precautions for handling 1-Butanethiol?

The Risks Behind 1-Butanethiol

Most people have not heard of 1-Butanethiol, but if you have worked in a lab or chemical plant, you know this clear liquid by its reputation. It smells like rotten cabbage, and that’s not just unpleasant—it’s a warning. Just a few drops in the wrong spot, and the room clears out. The harsh odor isn’t the biggest worry, though. The main issue comes from how even small exposures can irritate eyes, skin, and lungs.

Spills or splashes burn. Vapors sting the eyes and make breathing tough. Even trace amounts on your clothes follow you home. It lingers and spreads like wildfire. After a long shift, I’ve found my car seat reeking the next day, even after tossing my lab coat in the wash. It stubbornly clings to anything porous—gear, shoes, hair. At higher levels, the risk ramps up. Breathing the vapors can cause headaches and dizziness. There’s a real fire risk, too. 1-Butanethiol lights up easily, and those vapors mix with air to create explosive conditions if you aren’t watching the ventilation.

Safety Steps That Matter

Forget about shortcuts with bottles of this stuff. Start with a good fume hood—one that keeps a strong draw—and make sure it’s not just humming but actually working. Regular checks on the airflow save a lot of trouble down the line. Properly fitted goggles and a sturdy pair of chemical gloves mean everything; that tiny drop you miss can start an itch that spreads with each scratch.

Culture in labs makes or breaks good safety. There’s always someone tempted to loosen their face mask, especially after an hour in the hood. It’s just not worth it. I’ve seen coworkers with watery eyes and red arms from cutting corners on protective gear. The best way to reinforce these habits comes from open reminders and not making anyone feel foolish for double-checking their kit.

Good storage also prevents nasty surprises. 1-Butanethiol shouldn’t sit next to oxidizers or acids—cross-contamination spells trouble. Browning labels or sticky residue around a cap signal it’s time to swap out bottles and clean up. Spill kits for thiols need dedicated absorbents, as regular paper towels only spread the smell and the risk.

Health Is Worth the Precaution

Too many folks shrug off exposure because serious poisoning is rare. It’s easy to forget about the long-term health impact. Tight air quality tracking, mandatory annual training, and strong policies for reporting symptoms keep things on the rails. Supervisors should actually listen when people say they can smell the stuff down the hall. Nothing beats early action: quick handwashing, eye-wash stations close by, and training that drills “stop, drop tools, and report” over “try to fix it fast.”

Building Better Safety with Simple Steps

Beyond following specific rules, the attitude in the workplace shapes the outcome. If the team treats 1-Butanethiol like an everyday chemical, trouble follows. I worked alongside seasoned techs who could spot a bad gasket or worn cork by smell alone, but they still logged every error and cleaned every spill by the book. That’s not being too careful—it’s how you keep people healthy and keep the stink from becoming a disaster. Old lessons stick: respect every hazard, no matter how familiar. With enough practical steps, most accidents stay small, and everyone breathes easier by the end of the day.

What does 1-Butanethiol smell like?

1-Butanethiol: Odor Beyond Expectation

One whiff of 1-butanethiol knocks you back. Growing up on a farm, I’ve dealt with plenty of odors—skunk spray, rotting hay, manure on a hot day. 1-Butanethiol belongs in that club, right alongside the worst of the worst. Chemists often call it butyl mercaptan, but mention its name around anyone who’s opened a spill bottle, and you just get pained expressions. This stuff carries a smell that people don’t forget.

The Science of Its Stench

1-Butanethiol’s aroma comes from the sulfur atom tucked into its molecular structure. Sulfur lends an unforgiving sharpness that our noses register even at the tiniest trace. Humans detect this stuff at incredibly low concentrations—far below what you’d see in most lab work. Just one drop can ruin the air in a whole room. To give an idea, skunk spray and this chemical share that rotten, burned-rubber profile. That’s no exaggeration: professional odor experts use butanethiol as a reference point for calibrating stink meters.

Why Smell Has Real-World Impact

I once spent the afternoon in a lab after a flask of it cracked open. The memory stuck much longer than the smell did. The air turned thick with this nauseating, skunky sharpness—the kind of aroma that triggers disgust before the mind sorts out exactly what’s wrong. It clings to clothes, hair, even notebooks. At home, things like onion or garlic fade after a good scrub. 1-Butanethiol? Not so easily. That persistence makes it a safety concern. Leaks need quick, focused cleanup, and the ventilation better be strong.

Beyond Nuisance: Its Uses and Lessons

This chemical doesn’t exist just to punish the senses. It plays a role in industry—often as a warning agent. Much like how natural gas companies inject a similar sulfur compound to help trace leaks, the overpowering stink helps catch trouble fast. Without that rotten stench, invisible butahne leaks could go unnoticed until it’s too late. Researchers studying chemosensory systems also value it for training noses and setting detection thresholds.

Smell shapes more than comfort. I once saw a cleanup crew switch to full hazmat gear after a cap snapped off a small sample bottle. The company learned quickly about sealed storage, emergency air handling, and how fast a “minor” incident can disrupt business. In education, nothing drives home a lesson about chemical safety like being responsible for ventilating a building because a bottle rolled off a bench. One misstep leads to sharp learning—never let your guard down, practice careful labeling, and always know where to find clean air.

Solutions and Moving Forward

There’s no magic way to make 1-butanethiol pleasant. The answer lies in respect—strict container checks, double-bagging, and storing it where temperature swings stay mild and traffic remains light. Good labels save a lot of headache, and well-ventilated fume hoods earn every penny they cost. Training matters. Make sure everyone—students, lab pros, plant workers—understands exactly what a spill means and knows the steps for cleanup and evacuation. For science, the lessons from one nose-wrinkling encounter last for years.

How should 1-Butanethiol be stored?

Why Proper Storage Matters

1-Butanethiol carries a reputation for its strong, distinctive odor—the kind that can linger long after the bottle closes. People who spend time in labs or industrial facilities know the headache that comes when a chemical like this leaks or gets mishandled. Beyond the smell, 1-Butanethiol presents bigger problems: it’s flammable, forms hazardous vapors, and reacts with common oxidizers. I’ve seen minor mishaps with thiol compounds stretch into major headaches, with evacuation alarms blaring and entire workdays lost. Those moments do not just threaten productivity—they can undercut trust in safety routines. Taking short cuts comes with big risks.

Recognizing the Risks

On paper, 1-Butanethiol looks manageable, but there’s more to the story. This liquid catches fire at low temperatures, creates explosive air-vapor mixtures, and triggers nausea even at very low exposures. Researchers at the CDC have highlighted incidents where improper sealing led to vapor leaks that set off sensitive detectors in neighboring rooms. An unchecked leak can force entire buildings to clear out—no one enjoys that disruption, especially when a little diligence would have prevented the mess.

What Works in Practice

Glass containers with airtight, screw-capped lids take the edge off the worst odors and keep vapors from drifting. Those who work with medical-grade cabinets or chemical storage refrigerators will vouch for the difference that a well-maintained, ventilated flame-proof cabinet brings. Flammable chemical cabinets, properly grounded, keep the risk of fire and static in check. I’ve always stored thiols like 1-Butanethiol away from any acids and oxidizers, since cross-contamination ramps up the chance of dangerous reactions. The extra effort in labeling—bold, with clear hazard warnings—helps everyone on the team stay alert.

Ventilation: Breathing Room for Safety

Ventilation isn’t just a detail. Too many small spaces become the epicenter of headaches when poor airflow lets fumes build up. At my last facility, the difference between a hallway that smelled clean and one choked with thiol fumes always traced back to how well we kept vent fans running. Rooms dedicated to chemical storage should always push air outside, never recycling it back through common areas. Adding fume hoods around the main workspaces means any spills stay local, with less risk to the broader group.

Training and Communication

Everyone handling 1-Butanethiol needs to know what they’re up against. One forgotten cap can impact the entire building. Interactive, hands-on training makes a bigger impression than checklists. It is much easier to prevent problems when people recognize both the hazards and the simple safety steps that address them. Regular drills and visible reminders cut down on careless mistakes.

Real Solutions Earn Trust

Long-lasting safety comes from regular checks—inventory audits, seal inspections, and tracking expiration dates. Assigning direct responsibility, so each container has a point-person, creates accountability and consistency. It isn’t only about rules—it is about practical respect for one another’s health. Those who treat these steps as more than just compliance usually see stronger teams, cleaner record books, and less drama around hazardous chemicals.

Moving Toward Less Risk

Labs and factories owe it to their people to keep risky compounds like 1-Butanethiol as safe as possible. Purpose-built storage, clear communication, and a culture that addresses hazards head-on speak louder than equipment lists. It’s a matter of protecting everyday routines—and the communities that count on them staying safe and uneventful.

Is 1-Butanethiol soluble in water?

Looking at the Smell and Solubility

If you’ve spent any time in a chemistry lab, 1-butanethiol is a name you might connect with a sharp, pungent smell that lingers for days. This isn’t just another odd aroma in a bottle—this smell means something for how it behaves around water, too. In my own experience trying to clean glassware that’s touched this chemical, I’ve found that water alone won’t help much. The way it clings to surfaces says plenty about its relationship with water.

Understanding Why it Stays Separate

Examining 1-butanethiol’s structure shines a light on the problem. Its backbone stretches across four carbon atoms, backed by a thiol group at the end. Water thrives on hydrogen bonds and usually welcomes similar compounds. With 1-butanethiol, though, the large nonpolar tail keeps most of the molecule away, while the tiny –SH group doesn’t interact well enough to make up for the rest. Only small alcohols and simple thiols blend smoothly into water—the longer the tail, the less it mixes. This one just doesn’t play along; less than a gram dissolves in a liter of water at room temperature. Real-world testing, like pouring it into water in the lab, shows a separate, oily layer almost immediately. Any attempts to shake the two together only produce short-lived clouds that settle out quickly. The science lines up with what anyone can see with their own eyes.

Practical Impact Outside the Lab

The low solubility has everyday consequences. In industrial safety, workers dealing with leaks can’t just wash it away with water. It clings, and its powerful odor spreads fast, alerting people even if only a tiny amount escapes. This isn’t just a nuisance; thiols cause headaches, nausea, and more serious effects in high concentrations. In emergencies, merely flooding the area with water won’t clear the stink or the risk—chemical absorbents, plenty of ventilation, and appropriate personal protective gear make a bigger difference.

Environmental Perspective

Spilled 1-butanethiol in waterways follows oil’s path, floating on top rather than mixing through. Wildlife feels the impact, especially aquatic organisms sensitive to even trace amounts of chemical taint. Because it does not dissolve, cleanup after spills involves skimming and absorbing, echoing methods used for small oil slicks. The chemical’s persistence means it turns up long after an accident, sometimes detected just by the human nose before lab instruments ever get involved. Its low solubility acts like an early warning system, but the flip side is that environmental persistence grows.

Safer Handling and Spill Response

Situations involving this compound demand more than just rinse-and-repeat methods. In my own work, labs stored 1-butanethiol in double-sealed glass bottles with specific chemical-resistant gloves and fume hoods. Cleanup kits always included not just soap and water but clay-based absorbents and odor-neutralizing solutions with oxidizers. Training made a difference; we drilled for spill scenarios that called for evacuating people if the odor crept beyond a certain room threshold.

Building a Responsible Approach

Scientific know-how isn’t just a classroom thing—it shows up in the way people act in real-world situations. Companies that work with strong-smelling, stubborn compounds focus on air monitoring, emergency drills, and thoughtful design of storage rooms. Thinking ahead means fewer accidents, faster responses, and less environmental damage. Water alone can’t solve everything, especially for chemicals like 1-butanethiol. Working smarter keeps people safe and preserves the environment for the long haul.

1-Butanethiol
Names
Preferred IUPAC name butane-1-thiol
Other names Butyl mercaptan
Butanethiol
n-Butyl mercaptan
n-Butanethiol
1-Butylthiol
Pronunciation /ˈbjuːtəˌnaɪˌθaɪɒl/
Identifiers
CAS Number 109-67-1
Beilstein Reference 1209240
ChEBI CHEBI:35988
ChEMBL CHEMBL16858
ChemSpider 5055
DrugBank DB01938
ECHA InfoCard 100.003.710
EC Number 211-184-2
Gmelin Reference 82136
KEGG C02105
MeSH D001070
PubChem CID 8010
RTECS number EO1400000
UNII 7BBV52H1LU
UN number UN2347
Properties
Chemical formula C4H10S
Molar mass 90.19 g/mol
Appearance Colorless liquid
Odor disagreeable, skunk-like
Density Butanethiol has a density of 0.832 g/mL at 25 °C
Solubility in water 5.73 g/L (20 °C)
log P 1.88
Vapor pressure 3.9 kPa (at 20 °C)
Acidity (pKa) 10.5
Basicity (pKb) 14.0
Magnetic susceptibility (χ) -63.0·10⁻⁶ cm³/mol
Refractive index (nD) 1.417
Viscosity 0.849 cP (20°C)
Dipole moment 1.60 D
Thermochemistry
Std molar entropy (S⦵298) 201.7 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) -135.3 kJ·mol⁻¹
Std enthalpy of combustion (ΔcH⦵298) -3142.7 kJ/mol
Hazards
GHS labelling GHS02, GHS06, GHS08
Pictograms GHS02, GHS06, GHS08, GHS09
Signal word Danger
Hazard statements H225, H302, H315, H319, H332, H335, H410
Precautionary statements P210, P233, P261, P264, P270, P271, P273, P301+P310, P303+P361+P353, P304+P340, P305+P351+P338, P307+P311, P311, P312, P330, P340, P361, P363, P370+P378, P391, P403+P235, P405, P501
Flash point 38 °C (100 °F; 311 K)
Autoignition temperature 310 °C
Explosive limits 1-4.6%
Lethal dose or concentration LD50 oral rat 190 mg/kg
LD50 (median dose) LD50 (median dose): Oral-rat 385 mg/kg
NIOSH MU9275000
PEL (Permissible) PEL (Permissible Exposure Limit) for 1-Butanethiol: 1 ppm (3 mg/m³)
REL (Recommended) '5 ppm'
IDLH (Immediate danger) 100 ppm
Related compounds
Related compounds Methanethiol
Ethanethiol
Propanethiol
2-Butanethiol