Material Safety Data Sheet for Diethyl Disulfide

Identification

Product Name: Diethyl Disulfide
Chemical Formula: C4H10S2
CAS Number: 110-81-6
Synonyms: Diethyl disulphide; Ethyl disulfide
Recommended Use: Intermediate in organic synthesis, solvent, flavoring agent
Supplier: [Manufacturer or Distributor Information]
Contact Phone: [Emergency Phone Number]
Emergency Overview: Clear, colorless to pale yellow liquid with strong odor similar to decaying vegetables, garlic, or onions, used mostly in chemical industry and laboratories requiring disulfide compounds.

Hazard Identification

GHS Classification: Flammable liquid (Category 3), Acute toxicity oral (Category 4), Acute toxicity inhalation (Category 4), Acute toxicity dermal (Category 4), Skin and eye irritant (Category 2)
Signal Word: Warning
Hazard Statements: May cause respiratory, eye, and skin irritation; harmful if swallowed, inhaled, or in contact with skin; forms explosive mixtures with air; vapors heavier than air
Precautionary Statements: Avoid breathing vapors or mist, use only outdoors or in a well-ventilated area, wash skin after handling, wear protective gloves and safety goggles, keep away from sparks and open flame, use grounded equipment, keep containers tightly closed
Pictograms: Flame, exclamation mark, health hazard

Composition / Information on Ingredients

Chemical Identity: Diethyl Disulfide
Concentration: 98-100%
CAS Number: 110-81-6
Impurities: Trace amounts of related disulfides or sulfur compounds
Molecular Weight: 122.25 g/mol
EC Number: 203-892-1

First Aid Measures

Inhalation: Remove exposed person to fresh air, keep warm and at rest, seek medical attention if symptoms like cough, headache, or dizziness appear
Skin Contact: Remove contaminated clothing, wash affected area with soap and water for several minutes, seek medical care for irritation or burns
Eye Contact: Rinse cautiously with water for at least 15 minutes, lift eyelids to ensure thorough flushing, get medical advice if irritation persists
Ingestion: Do not induce vomiting, rinse mouth with water, seek immediate medical attention, never give anything by mouth to an unconscious individual
General Advice: Show this safety sheet to medical personnel

Fire-Fighting Measures

Flammability: Flammable liquid and vapor
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam, alcohol-resistant foam
Unsuitable Extinguishing Media: Do not use direct water streams
Special Hazards: Vapors may form explosive mixtures in air, may produce toxic sulfur oxides when burned
Protective Equipment: Wear full protective gear and self-contained breathing apparatus
Fire Fighting Instructions: Move containers from fire area if possible, avoid breathing combustion products which may include sulfur dioxide, use water spray to cool unopened containers
Explosion Data: Vapors can travel to source of ignition and flash back

Accidental Release Measures

Personal Precautions: Evacuate unnecessary personnel, avoid breathing vapors, use personal protection including gloves, goggles, and chemical-resistant clothing
Environmental Precautions: Prevent spillage from entering drains, watercourses, and soil
Containment: Eliminate all ignition sources, ventilate the area, stop leak if safe to do so
Clean-Up Methods: Absorb with inert material such as sand or earth, collect in suitable closed containers, flush area with water after pickup, dispose of according to local regulations
Decontamination: Use appropriate cleaning agents, avoid using combustible absorbents

Handling and Storage

Handling: Keep containers tightly sealed, use in well-ventilated spaces, ground and bond containers, avoid contact with eyes, skin, and clothing, do not breathe vapor or mist, wash hands thoroughly after handling
Storage: Store in a cool, dry, well-ventilated place away from incompatible substances such as strong oxidizers and acids, keep away from direct sunlight, prohibit smoking and open flames in storage area, use corrosion-resistant containers, keep container upright and tightly closed when not in use
Specific End Uses: Uses described in section 1 of MSDS, follow industry guidelines for handling chemicals of this type

Exposure Controls and Personal Protection

Exposure Limits: No established OSHA or ACGIH limits; handle minimizing exposure
Engineering Controls: Use chemical fume hood, local exhaust, or other engineering controls to keep airborne levels below recommended exposure limits
Respiratory Protection: Approved respirators recommended when ventilation is limited or in emergency situations
Skin Protection: Wear chemically resistant gloves (nitrile, neoprene), long-sleeved clothing, and face shield when splashing possibility exists
Eye Protection: Use safety goggles and/or full-face shield
Hygiene Measures: Wash hands before breaks and after handling, avoid contamination of personal items, change contaminated clothing before reusing

Physical and Chemical Properties

Appearance: Clear, colorless to pale yellow liquid
Odor: Strong, pungent, sulfurous odor
Odor Threshold: Extremely low, odor detectable at sub-ppm concentrations
pH: Not applicable
Melting Point/Freezing Point: -85°C
Boiling Point: 152°C
Flash Point: 43°C (Closed cup)
Evaporation Rate: Not determined
Flammability: Flammable at room temperature
Vapor Pressure: 4 mmHg @ 25°C
Vapor Density: 4.2 (air = 1)
Relative Density: 1.00 (water = 1)
Solubility: Low in water; miscible with organic solvents
Partition Coefficient (n-octanol/water): log Kow ~ 2.2
Auto-Ignition Temperature: 235°C
Decomposition Temperature: Not determined
Viscosity: Not determined

Stability and Reactivity

Chemical Stability: Stable under recommended handling and storage conditions
Reactivity: Can react with strong oxidizers, acids, and bases
Hazardous Reactions: Risk of exothermic reaction with incompatible substances, formation of toxic sulfur compounds when heated or combusted
Conditions to Avoid: Heat, open flames, sparks, exposure to oxidizers
Incompatible Materials: Strong acids, oxidizing agents, peroxides
Hazardous Decomposition Products: Sulfur oxides, hydrogen sulfide, other toxic gases
Polymerization: Will not occur under normal conditions

Toxicological Information

Acute Toxicity: Harmful by ingestion, inhalation, and skin absorption; LD50 oral (rat) 260 mg/kg; LD50 dermal (rabbit) 2,000 mg/kg
Skin Corrosion/Irritation: Causes skin irritation on contact
Eye Damage/Irritation: Causes moderate eye irritation
Respiratory Sensitization: May cause irritation to the mucous membranes and respiratory tract
Skin Sensitization: Not expected to cause skin sensitization
Germ Cell Mutagenicity: No data available
Carcinogenicity: Not classified as a human carcinogen by IARC, NTP, OSHA
Reproductive Toxicity: No data available on adverse reproductive effects
STOT - Single Exposure: May cause transient dizziness, headaches, nausea
STOT - Repeated Exposure: Prolonged inhalation or repeated contact may produce chronic effects in liver or blood
Aspiration Hazard: No data for aspiration risk

Ecological Information

Ecotoxicity: Toxic to aquatic organisms; LC50 (fish, 96h): 3.2 mg/L; EC50 (Daphnia, 48h): 1.5 mg/L; can affect microbial activity
Persistence and Degradability: Moderately biodegradable; photolysis and oxidation in atmosphere expected
Bioaccumulative Potential: Moderate potential based on log Kow
Mobility in Soil: Low to moderate, volatile and can partition to air
Other Adverse Effects: High concentrations in water or soil may have toxic impact on organisms, avoid contamination of natural waters

Disposal Considerations

Waste Disposal: Treat as hazardous waste; incinerate in a chemical incinerator equipped with afterburner and scrubber, consult local, state, or national legislation
Contaminated Packaging: Rinse well; dispose of as hazardous material
Special Precautions: incineration preferred for large volumes, avoid discharge to environment, ensure full compliance with waste control authorities and environmental protection regulations

Transport Information

UN Number: UN 2381
UN Proper Shipping Name: Diethyl disulfide
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Environmental Hazards: Marine pollutant; avoid spills into watercourses
Special Precautions for Users: Keep away from sources of ignition, transported in tightly sealed containers, emergency response guide number 128
Transport in Bulk: Not regulated for bulk shipment as per MARPOL/IBC code

Regulatory Information

US OSHA: Classified hazardous under OSHA Hazard Communication Standard
TSCA: Listed on the TSCA inventory
SARA Title III (Sections 311/312): Acute health hazard, fire hazard
EU REACH: Pre-registered substance, comply with REACH regulations if manufactured or imported in Europe
DSL (Canada): Listed
Other Regulations: Ensure compliance with all local, national, and regional regulations regarding handling, storage, use, and transportation of hazardous chemicals, always consult country-specific guidelines for safety and environmental protection