Material Safety Data Sheet for Dithiodiglycolic Acid

Identification

Product Name: Dithiodiglycolic acid
Chemical Name: 2,2'-Dithiodiacetic acid
Synonyms: Dithioglycolic acid, Dithiodiglycolic acid
CAS Number: 505-56-6
Recommended Use: Laboratory reagent, chemical synthesis intermediate
Supplier Information: Chemical manufacturer or distributor, address, emergency contact number provided by specific source

Hazard Identification

GHS Classification: Acute toxicity (oral, skin, inhalation), Skin irritation, Eye irritation, Specific target organ toxicity
Signal Word: Warning
Hazard Statements: Harmful if swallowed or in contact with skin. Causes skin and serious eye irritation. Toxic to aquatic life with long lasting effects.
Pictograms: Exclamation mark, environment, health hazard
Precautionary Statements: Avoid breathing dust or vapors. Wear protective gloves, clothing, and eye protection. Wash thoroughly after handling. Prevent release to the environment.

Composition / Information on Ingredients

Chemical Identity: Dithiodiglycolic acid
Concentration: 98-100% depending on supplier
CAS Number: 505-56-6
Impurities/Additives: Trace water, contaminants may vary based on synthesis

First Aid Measures

Inhalation: Move to fresh air, seek medical support if symptoms develop including coughing, headache, or breathing difficulty.
Skin contact: Remove contaminated clothing. Immediately wash exposed skin with plenty of water and soap. Seek medical attention if irritation persists.
Eye contact: Rinse cautiously with water for at least 15 minutes, lifting eyelids. Remove contact lenses if easily possible. Seek immediate medical attention.
Ingestion: Rinse mouth with water if conscious, do not induce vomiting, seek medical advice immediately.
Most Important Symptoms: Burning sensation, redness or blistering on skin and eyes, systemic toxicity in severe cases
Notes for Medical Personnel: Provide symptomatic treatment and monitor vital signs

Fire-Fighting Measures

Suitable Extinguishing Media: Use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray.
Unsuitable Extinguishing Media: Never use a direct water jet as reaction may spread the substance.
Specific Hazards: Product combustion may release sulfur oxides and toxic fumes.
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear.
Fire-Fighting Instructions: Prevent runoff into drains or water bodies; cool containers with water spray to avoid rupture from heat.

Accidental Release Measures

Personal Precautions: Evacuate unnecessary personnel, secure adequate ventilation, avoid skin or eye contact.
Protective Equipment: Wear chemical-resistant gloves, safety goggles, and protective clothing.
Spill Clean-Up Procedures: Cover spill with inert absorbent material such as sand or vermiculite. Collect carefully into labeled containers.
Environmental Precautions: Prevent further leakage or spillage; do not allow to enter drains, sewers, surface or ground water
Disposal: Dispose in accordance with local, regional and national regulations; consult an authorized waste handler.

Handling and Storage

Handling Precautions: Handle only in area with adequate ventilation. Avoid inhalation, ingestion, and contact with skin, eyes, and clothing.
Hygiene Measures: Wash hands and exposed skin after handling; keep contaminated work clothing separate.
Storage Conditions: Store in tightly closed container, in cool, dry and well-ventilated area away from incompatible substances like strong oxidizers and bases.
Incompatible Materials: Store away from bases, strong oxidizing agents, and reducing agents. Do not store with food, drink, or animal feed.

Exposure Controls and Personal Protection

Engineering Controls: Use fume hood, proper exhaust ventilation to minimize airborne exposure.
Occupational Exposure Limits: No established exposure limits; follow general chemical hygiene guidelines.
Personal Protective Equipment: Wear chemical-splash goggles, resistant gloves (nitrile or neoprene), laboratory coat, and use respiratory protection if ventilation is inadequate.
Environmental Exposure Controls: Prevent uncontrolled environmental release; use secondary containment if risk of leak exists.

Physical and Chemical Properties

Appearance: Colorless to pale yellow crystalline powder or solid
Odor: Slight sulfur odor
Odor Threshold: Not determined
pH (1% solution): Acidic, pH <2
Melting Point: 125-130°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Flammability: Not classified as flammable
Vapor Pressure: Not established at room temperature
Solubility: Moderately soluble in water, soluble in polar organic solvents
Relative Density: Approx. 1.6 g/cm³
Partition Coefficient (log Kow): Not available
Auto-ignition Temperature: Not determined
Decomposition Temperature: Above melting point, releases toxic gases
Viscosity: Not applicable (solid)

Stability and Reactivity

Reactivity: Reactive with oxidizing agents and strong bases
Chemical Stability: Stable under recommended storage conditions
Possibility of Hazardous Reactions: May react exothermically with strong oxidizers or bases
Incompatible Materials: Chlorinated compounds, alkali metals, strong acids or bases
Hazardous Decomposition Products: Sulfur oxides (SOx), carbon monoxide, carbon dioxide when heated to decomposition

Toxicological Information

Likely Routes of Exposure: Ingestion, inhalation, skin and eye contact
Acute Toxicity: LD50 (oral, rat) estimated at 200-500 mg/kg
Skin Corrosion/Irritation: Causes skin irritation and possible chemical burns
Serious Eye Damage/Irritation: Causes serious eye irritation, possible corneal injury
Respiratory Sensitization: May cause respiratory irritation if inhaled as dust
Other Potential Effects: Headache, dizziness, nausea upon exposure
Chronic Effects: Prolonged or repeated exposure may damage organs or lead to sensitization

Ecological Information

Ecotoxicity: Highly toxic to aquatic organisms, may cause long-term adverse effects in aquatic environments
Persistence and Degradability: Limited data; estimated moderate persistence; sulfur bonds can resist rapid biodegradation
Bioaccumulation Potential: Expected to have some potential for bioaccumulation due to molecular structure
Mobility in Soil: Moderate mobility; may leach to groundwater under certain conditions
Other Adverse Effects: Contributes to acidification of water and soil ecosystems

Disposal Considerations

Waste Disposal Methods: Incinerate in chemical incinerator equipped with afterburner and scrubber as permitted by local regulations; avoid landfill disposal where possible
Contaminated Packaging: Dispose of as hazardous waste; triple rinse and deliver to hazardous waste handler
Special Precautions: Do not discharge to sewer or natural environment

Transport Information

UN Number: UN 3261
UN Proper Shipping Name: Corrosive solid, acidic, organic, n.o.s. (Dithiodiglycolic acid)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II (medium danger)
Environmental Hazards: Marine pollutant
Transport Precautions: Keep packaging intact, segregate from foods and feedstuffs, carry under security provisions for hazardous substances

Regulatory Information

EU Regulations: Classified according to Regulation (EC) No 1272/2008 (CLP). Requires labeling with hazard pictograms and statements.
US Regulations: Subject to reporting under Section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA). SDS must be available on-site.
TSCA Status: Listed or subject to applicable TSCA controls
Other International: Japanese Industrial Standards and Canadian WHMIS apply. Registrations and restrictions will differ according to local legislation.
Workplace Controls: Employers must provide training and ensure safe practices in handling.